Tag: Africa

Global Phase 3 INDIGO study will evaluate the efficacy and safety of obexelimab in patients with IgG4-RD, a chronic and serious fibroinflammatory disease typically affecting multiple organs

IgG4-RD is the first of several potential disease indications to be pursued for obexelimab given its unique non-depleting, B-cell inhibition

WALTHAM, Mass., Jan. 11, 2023 (GLOBE NEWSWIRE) — Zenas BioPharma, a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune-based therapies, today announced that the first patient has been dosed in the INDIGO Phase 3 registrational study of obexelimab. The INDIGO study will evaluate the clinical efficacy and safety of obexelimab treatment in the prevention of IgG4-related disease (IgG4-RD) flare. Obexelimab is a high-affinity bifunctional antibody that inhibits B-cell lineages by simultaneously binding to CD19 and Fc_ƳRIIB, thereby downregulating B-cell activity in patients with autoimmune diseases associated with autoantibodies, such as IgG4-RD.

“IgG4-RD is a chronic and serious fibroinflammatory condition that can affect nearly any organ system and can have a profound impact on many patients, leading to severe organ damage or death,” said Hua Mu, M.D., Ph.D., Chief Executive Officer at Zenas. “There are no currently approved treatments for patients living with IgG4-RD. Based upon the promising data from a Phase 2 study of obexelimab in IgG4-RD patients, we are excited to continue to evaluate the potential of obexelimab in the INDIGO study.”

About the INDIGO Study

The INDIGO study is a global multicenter, randomized, double-blind, placebo-controlled study enrolling up to 200 adults with active IgG4-RD signs/symptoms (i.e., flare) that require steroid therapy. Patients will be randomized in a ratio of 1:1 to receive either obexelimab or placebo, administered as subcutaneous injections.

The primary endpoint of INDIGO is time to first IgG4-RD flare (defined as the reappearance of previous signs/symptoms or appearance of new signs/symptoms of IgG4-RD) that requires initiation of rescue therapy from randomization to Week 52. Safety will be evaluated throughout the study duration.

More information on the INDIGO study (NCT05662241) is available at clinicaltrials.gov.

About Obexelimab

Obexelimab is an investigational Phase 3-stage, novel bifunctional antibody with first-in-class potential that inhibits B-cell lineages that express CD19. Simultaneous binding to CD19 and Fc_ƳRIIB by obexelimab mimics a natural antigen-antibody complex and downregulates B cell activity. In several early-stage clinical studies, 198 subjects were treated with obexelimab. In these clinical studies, the molecule demonstrated effective inhibition of B cell function without depleting the cells and generated an encouraging treatment effect in patients with multiple autoimmune diseases. Zenas acquired exclusive worldwide rights to obexelimab from Xencor, Inc.

About IgG4-RD

IgG4-RD is a chronic and serious fibroinflammatory disease typically affecting multiple organs (e.g., pancreas, liver, kidney, bile duct, salivary and lacrimal glands). Approximately 20,000 people are diagnosed with IgG4-RD in the US, with similar prevalence rates across geographies. Many patients have some degree of irreversible organ damage at the time of diagnosis. Although nearly all patients initially respond to glucocorticoid (GC) therapy, a majority of patients will relapse/flare within a few months of discontinuing treatment, requiring rescue therapy. Chronic GC therapy is also associated with toxicity in many patients.

About Zenas BioPharma

Zenas BioPharma is a global biopharmaceutical company committed to becoming a leader in the development and commercialization of immune-based therapies for patients around the world. With clinical development and operations globally, Zenas is advancing a deep and balanced global portfolio of potential first- and best-in-class autoimmune therapeutics in areas of high unmet medical need while meeting the value requirements of the dynamic global healthcare environment. The company’s pipeline continues to grow through our successful business development strategy. Our experienced leadership team and network of business partners drive operational excellence to deliver potentially transformative therapies to improve the lives of those living with autoimmune and rare diseases. For more information about Zenas BioPharma, please visit www.zenasbio.com and follow us on Twitter at @ZenasBioPharma and LinkedIn.

Investor and Media Contact:
Joe Farmer, President & COO
Zenas BioPharma
IR@zenasbio.com

GlobeNewswire Distribution ID 8727743

TEMECULA, Calif., Jan. 10, 2023 (GLOBE NEWSWIRE) — Nikkiso Clean Energy & Industrial Gases Group (“Group”), a part of the Nikkiso Co., Ltd (Japan) group of companies, is proud to announce its first on-site FAT testing at their new Marine facility in Busan, Korea. This accomplishment exemplifies their commitment to and support of the growth of the Korean market.

Since July 2022, they have been fabricating high-pressure pump skids in the 4,000 square meter facility. With the successful completion of this FAT test for Hapag Lloyd AG (for the largest fuel gas supply system), they demonstrate the capabilities of their factory and its LN2 (liquid nitrogen) test facility. This facility continues to provide the commissioning and maintenance support previously provided. With the HP pumps skid fabrication and testing capabilities, they now provide full-system marine solutions to their customers.

The FAT test is mandatory prior to skid delivery, which tests for overall performance (i.e., pump maximum flowrate, vaporizer performance, lube-oil (LO) system, nitrogen purge system, cryogenic valves, etc.). It must be witnessed by shipowner, class society, and customers, verifying the product meets its performance requirements.

According to Jay Lee, General Manager, Korea, “Nikkiso ACD has been the preferred supplier for Fuel Gas skids to the Korean shipbuilding industry for over 20 years! With our new skid packaging and testing facility located near the shipyards in Korea, we now have even greater capacity to provide local support and meet the significant global marine demands.”

“This is an important next step for our Group and the LNG powered Marine market, and an expanded benefit for our Marine customers. Nikkiso CE&IG will now be able to provide and test full systems and support our customers with a turnkey system solution,” according to Peter Wagner, CEO of Cryogenic Industries and President of the Group.

Contact Information:
Nikkiso Clean Energy and Industrial Gases – Korea
Head Office & Factory: 83, Nosansanupjung-ro, Gangseo-gu, Busan, 46752, Korea
Branch office: #1912, 170, Gwanggyojungang-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16614, Korea
info@NikkisoCEIG-Korea.com

ABOUT CRYOGENIC INDUSTRIES
Cryogenic Industries, Inc. (now a member of Nikkiso Co., Ltd.) member companies manufacture and service engineered cryogenic gas processing equipment (pumps, turboexpanders, heat exchangers, etc.) and process plants for Industrial Gases, and Natural Gas Liquefaction (LNG), Hydrogen Liquefaction (LH2) and Organic Rankine Cycle for Waste Heat Recovery. Founded over 50 years ago, Cryogenic Industries is the parent company of ACD, Nikkiso Cryo, Nikkiso Integrated Cryogenic Solutions, Cosmodyne and Cryoquip and a commonly controlled group of 20 operating entities.

For more information, please visit www.nikkisoCEIG.com and www.nikkiso.com.

MEDIA CONTACT:
Anna Quigley
+1.951.383.3314
aquigley@cryoind.com

GlobeNewswire Distribution ID 8727431

DUBAI, United Arab Emirates, Jan. 11, 2023 (GLOBE NEWSWIRE) — FURA Gems announced today it had initiated the certification process with the RJC, demonstrating its commitment to responsible business practices. The project will be headed by Mazars Switzerland, which will accompany FURA Gems and all its operating mining locations in Colombia for emeralds, Mozambique for rubies, and Australia for sapphire through the process of RJC preparation. FURA has already registered its Australian location with RJC, and FURA will now look to expand the certification for the group and all its operating sites. With Mazar’s support, FURA will target to complete the certification process on or before December 31, 2023, for all its operating locations.

The certification with RJC is part of the ambitious ESG strategy deployed by FURA since its foundation in 2017. Earlier last year, FURA announced the partnership with Gübelin to provide traceability for all its stones through the Provenance Proof Blockchain. RJC Certification marks an additional important step towards achieving FURA’s ambitious ESG goals.

“This is a strong statement from our side, as we launch certification of all our mines producing emeralds, rubies and sapphires,” says Dev Shetty, Founder & CEO of FURA Gems. “The certification process will enable us to formalize our commitment since our foundation: to provide the jewellery market with traceable, sustainably sourced colour gemstones. To achieve this, we have identified Mazars as the ideal partner to conduct the process throughout our production sites and at the headquarters level. Mazars offers the ideal combination of regional expertise and global perspective, enabling us to conduct the project with the greatest level of competencies & professionalism.”

Franck Paucod, Partner at Mazars, explains, “We are thrilled to accompany FURA Gems through the demanding process of RJC COP Certification. Conducting the project for the three (3) mines simultaneously shows FURA’s commitment to responsible mining. We are confident that with our experiences in the gems and jewellery sector, we will be able to support FURA with its commitment to building the solid framework to achieve the RJC certification.”

ABOUT FURA GEMS

FURA Gems Inc. is a coloured gemstone mining and marketing company established in 2017. Headquartered in Dubai, United Arab Emirates, FURA has over 1,200 employees across continents. It is the first pioneering, creative and ethical enterprise to cover the entire spectrum of coloured gemstones. It operates three mining subsidiaries in Colombia, Mozambique, and Australia that mines emeralds, rubies, and sapphires. FURA also initiated its exploration program in Madagascar for sapphire mining. It is the fastest-growing coloured gemstone mining company to ensure the stability and traceability of ethically mined coloured gemstones from rough to retail.

ABOUT MAZARS

Mazars is an internationally integrated partnership, specialising in audit, accountancy, advisory, tax and legal services. Operating in over 90 countries and territories around the world, Mazars draws on the expertise of more than 44,000 professionals to assist clients of all sizes at every stage in their development.

Mazars Switzerland is specialised in the watch & jewellery industry. Mazars can either accompany clients throughout the RJC Code of Practice COP certification preparation and registration which is the case for FURA Gems or perform audits for the certification of companies in conformity of the RJC COP.

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/80695a84-8e96-48d7-a21d-6548f0e035e7

FURTHER INFORMATION

Gianluca Maina, Marketing Director, FURA Gems, gianluca.maina@furagems.com

Franck Paucod, Partner, Mazars SA, franck.paucod@mazars.ch

GlobeNewswire Distribution ID 1000776648

New era for green tech alternatives to replace petrochemical synthesized dyes.

Bedford, Mass., Jan. 09, 2023 (GLOBE NEWSWIRE) — Conagen announced the successful scale-up of its sustainable, cost-effective Tyrian purple, a historically coveted and expensive dye found in rare and limited sources in marine nature.

Conagen is the world’s first and only biotechnology company commercializing a sustainable Tyrian purple by fermentation. As with any biologically-sourced textile dye, this color-fast compound reduces pollution and carbon footprints when used as an alternative to petrochemically synthesized dyes commonly used in the textiles industry today.

Also known as Phoenician purple, royal purple, imperial purple, or imperial dye, this rare dye dates back several millennia to the bronze age when the Phoenicians from Tyre, Lebanon, on the Levantine coast, produced it for the ancient Greeks, Persians, Byzantines, and the Roman empire to clad emperors and kings with luxury textiles. Tyrian purple was once worth more than its weight in gold for its prized deep rich purple. In 301 CE, during the Roman Empire, one pound of Tyrian purple dye was priced at approximately three Troy pounds of gold, roughly $66,000 in today’s currency.

Current producers extract and harvest Tyrian purple from the murex shellfish in much the same way as the ancient Phoenicians. Thousands — approximately 10,000 or (54 kilograms (119 lb.) of these predatory sea snails are required to make diminishing quantities of Tyrian purple to produce 1 gram of the dye, making it impracticable, expensive, and environmentally unfriendly. Ancient dye producers all but drove the murex species to extinction along the coasts of Phoenicia, evident in the vast deposits of the shells excavated on the outskirts of Sidon, Tyre, and across the Mediterranean.

Conagen’s Tyrian purple, produced by precision fermentation and bioconversion, is a natural, sustainable dye ideal for textile companies under pressure to deliver fashions more sustainably and with a reduced global environmental footprint, especially from manufacturing.

“Conagen is democratizing the exclusive use of a color once reserved for royalty — now obtainable on a global scale,” said Casey Lippmeier, Ph.D., senior vice president of innovation. “Our fermentation and bioconversion technologies enable us to offer true-to-nature products. By leveraging Conagen’s bioengineering and commercial manufacturing capabilities, we’re unlocking Tyrian purple’s great potential as an accessible and sustainable dye. We expect Tyrian purple to inspire fresh ideas in multiple industries, making this rare and exciting color more marketable with planet-conscious consumers.”

The Tyrian purple technology is based on two of Conagen’s many key bioengineering platforms, which enable accelerated product development timelines for its competitive phenolics, terpenoids, proteins, and peptide molecules.

As an example, Conagen’s phenolics platform was used to make an important antioxidant, hydroxytyrosol, the active health ingredient found in oil, juice, and fruit in olives. Using another platform, Conagen has optimized the production of different amino acid-based products, including the nutraceutical antioxidant ergothioneine, a “longevity vitamin” currently branded as “Ergoactive” by Conagen’s pipeline partner Blue California. To produce the Tyrian purple, Conagen drew from both proprietary platforms to develop novel enzymes which increase the conversion efficiency of precursors to the dye.

“Conagen has further solidified its leadership in the bioeconomy by rapidly producing multiple novel and interesting molecules, such as Tyrian purple,” said Lippmeier. “Our technology platforms have been meticulously engineered and improved upon for over a decade, and they are extremely efficient at making targeted compounds from an expanding array of molecular classes for our internal product development and collaborative ventures.”

Conagen aims to replace petroleum-based ingredients and reduce carbon footprints with green technologies. Tyrian purple adds to Conagen’s natural color offerings, including several carotenoids made by fermentation which have been scaled to global production. As a dye, Tyrian purple is ideal for textile fabrics, clothing, handbags, and related accessories.

About Conagen

Conagen is making the impossible possible. Our scientists and engineers use modern synthetic biology tools to program micro-organisms and enzymes on a molecular level to produce high-quality, sustainable, natural products manufactured worldwide via precision fermentation and bioconversion. We focus on the bioproduction of high-value ingredients for food, nutrition, flavors and fragrances, pharmaceuticals, and renewable materials.

Attachments

• Bolinus brandaris, also called sea snail or purple dye murex
• Tyrian purple dye for textiles

Ana Arakelian, Head of Public Relations and Communications
Conagen
+1-781-271-1588
ana.arakelian@conagen.com

GlobeNewswire Distribution ID 8725973

Grid connection and power quality solution for the MFW Baltyk II and MFW Baltyk III offshore wind farms will help Poland progress towards its renewable energy goal and provide emission-free electricity for more than 2 million Polish homes.

Zurich, Switzerland, Jan. 09, 2023 (GLOBE NEWSWIRE) — Zurich, Switzerland, January 9, 2023 – Hitachi Energy, a global technology leader that is advancing a sustainable energy future for all, today announced it has won two major orders from Equinor and Polenergia to provide an AC grid connection and power quality solution for their jointly owned MFW Baltyk II and MFW Baltyk III offshore wind farms, with a combined generating capacity of 1,440 megawatts in the Polish sector of the Baltic Sea.

Hitachi Energy will provide each of the two wind farms with an offshore grid connection that will receive the power from the wind turbines and transfer it to shore, a mainland grid connection that will transmit the power into the national transmission system, and a STATCOM power quality solution to ensure that power flows reliably and stably at optimal capacity and at all times, despite the often high variability of wind power.

MFW Baltyk II and MFW Baltyk III are pending a final investment decision in 2024, and are scheduled to deliver first power in 2027. They will be one of the first offshore wind farms in Poland and part of the country’s ambitious program to develop its offshore wind potential and increase the use of renewables in its electricity mix, which historically is dominated by coal. The government aims to have around 11 gigawatts of offshore wind capacity either operational or under development by 2027¹.

Hitachi Energy was selected in a competitive procurement process on the strength of its front-end engineering and design (FEED) studies and optimized solutions, its long track record of project execution excellence, and its close working relationships over many decades with Equinor and PSE (Poland’s transmission system operator) and, most recently, Polenergia.

“Integrating large-scale renewable energy sources with the power grid is a key enabler of the energy transition and a field in which we have been a pioneer for decades,” said Niklas Persson, Managing Director of Hitachi Energy’s Grid Integration business. “Our grid connection technologies feature in offshore wind farms worldwide, and our power quality solutions resolve bottlenecks and keep the voltage stable and the energy flowing in power systems globally.”

These project awards further underscore Hitachi Energy’s position as a global leader in the offshore wind market and the partner of choice for wind farm developers, combining solid experience with grid technologies to help make the world’s energy system more sustainable, flexible and secure by enabling new solutions and business models to be deployed at scale and with speed.

The company has been continuously developing its portfolio to better serve this market with the recent launch of its Grid-eXpand range of modular and prefabricated grid connection solutions that make it faster, simpler and more efficient to connect offshore wind farms to mainland grids, and with its complete portfolio of STATCOMs and E-STATCOMs for all power ranges, ensuring grid stability and power quality at all times.

The announcement follows a recent global agreement between Hitachi Energy and Equinor to collaborate on high-voltage transmission systems (AC and DC) to connect Equinor offshore wind farms and production facilities to mainland power grids worldwide.

1Global Wind Energy Council – Global Offshore Wind Report 2022

About Hitachi Energy Ltd.

Hitachi Energy is a global technology leader that is advancing a sustainable energy future for all. We serve customers in the utility, industry and infrastructure sectors with innovative solutions and services across the value chain. Together with customers and partners, we pioneer technologies and enable the digital transformation required to accelerate the energy transition towards a carbon-neutral future. We are advancing the world’s energy system to become more sustainable, flexible and secure whilst balancing social, environmental and economic value. Hitachi Energy has a proven track record and unparalleled installed base in more than 140 countries. Headquartered in Switzerland, we employ around 40,000 people in 90 countries and generate business volumes of approximately $10 billion USD.

https://www.hitachienergy.com

https://www.linkedin.com/company/hitachienergy

https://twitter.com/HitachiEnergy

About Hitachi, Ltd.

Hitachi drives Social Innovation Business, creating a sustainable society with data and technology. We will solve customers’ and society’s challenges with Lumada solutions leveraging IT, OT (Operational Technology) and products, under the business structure of Digital Systems & Services, Green Energy & Mobility, Connective Industries and Automotive Systems. Driven by green, digital, and innovation, we aim for growth through collaboration with our customers. The company’s consolidated revenues for fiscal year 2021 (ended March 31, 2022) totaled 10,264.6 billion yen ($84,136 million USD), with 853 consolidated subsidiaries and approximately 370,000 employees worldwide. For more information on Hitachi, please visit the company’s website at https://www.hitachi.com.

Attachment

• Hitachi Energy awarded major orders to integrate two large offshore wind farms with Poland’s power grid

Jocelyn Chang
Hitachi Energy
+41793847775
jocelyn.chang@hitachienergy.com

GlobeNewswire Distribution ID 8725982